Tapentadol is a prescription medication used to treat moderate to severe pain. It is classified as an opioid analgesic and norepinephrine reuptake inhibitor (NRI), which means it works in two ways: it activates opioid receptors in the brain to reduce the perception of pain, and it inhibits the reuptake of norepinephrine, enhancing the body’s pain-relieving response. Tapentadol Often prescribed for conditions like post-surgical pain, chronic pain (e.g., due to musculoskeletal disorders), and neuropathic pain. It is available in immediate-release and extended-release formulations.