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A synthetic opioid painkiller called tramadol is used to treat moderate to severe pain. It functions by attaching itself to brain opioid receptors, which lessens the experience of pain. Chronic pain, pain following surgery, and pain related to illnesses like osteoarthritis are among the reasons for which tramadol is frequently recommended. Tramadol is special in that it functions similarly to other antidepressants by acting as a serotonin and norepinephrine reuptake inhibitor.

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