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A synthetic opioid painkiller called tramadol is used to treat moderately to severely severe pain. It reduces the experience of pain by attaching to opioid receptors in the brain. Osteoarthritis, chronic pain, and post-surgical pain are among the illnesses for which tramadol is frequently recommended. Tramadol is distinct in that it functions similarly to some antidepressants by acting as a serotonin and norepinephrine reuptake inhibitor. Its ability to function in two ways could be a factor in how well it manages specific kinds of pain.

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