Get 10% Discount Apply Coupon Code "USA10" Analgesics that are synthetic and used to treat moderate to severe pain include tramadol. It reduces the experience of pain by attaching itself to opioid receptors in the brain. Pain related to diseases like osteoarthritis, persistent pain, and pain following surgery are among the illnesses for which tramadol is frequently recommended. Tramadol is special in that, like several antidepressants, it also functions as a serotonin and norepinephrine reuptake inhibitor.