Get 10% Discount Apply Coupon Code "USA10" Pain ranging from moderate to severe is the main indication for the prescription drug tramadol. It's a member of the opioid analgesics class of medications. Tramadol inhibits the perception and response to pain in the body by attaching itself to opioid receptors in the brain. Tramadol has several effects that are similar to those of an antidepressant in certain people, in addition to its ability to relieve pain. These effects include suppression of serotonin and norepinephrine reuptake.