Get 10% Discount Apply Coupon Code "USA10" For the treatment of mild to fairly severe pain, the synthetic opioid painkiller tramadol is employed. In addition to its mild suppression of serotonin and norepinephrine reuptake, it acts via binding to opioid receptors in the brain and spinal cord. For a variety of pain problems, including neuropathic pain, osteoarthritis, and postoperative pain, tramadol is frequently recommended.