Get 10% Discount Apply Coupon Code "USA10" A synthetic opioid painkiller called tramadol is used to treat moderate to severe pain. Like other opioids, it acts by attaching to opioid receptors in the brain, but it also has other methods of action that help it relieve pain. For ailments like post-surgical pain, joint pain, and back pain, tramadol is frequently recommended. Tramadol is special in that it acts on opioid receptors but also raises brain levels of neurotransmitters like norepinephrine and serotonin, which may help explain why it has analgesic effects. It differs from other opioids due to its dual mode of action.