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Tapentadol is a centrally acting opioid analgesic, commonly used to manage moderate to severe pain. It works by binding to mu-opioid receptors in the central nervous system, exerting both opioid agonist activity and norepinephrine reuptake inhibition. Tapentadol is used for the treatment of acute pain, such as pain following surgery, as well as chronic pain conditions like diabetic neuropathy. Tapentadol has a dual mechanism of action. It acts as an opioid agonist (similar to morphine) and also inhibits the reuptake of norepinephrine. This dual action contributes to its analgesic effects.

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