Get 10% Discount Apply Coupon Code "USA10" Tapentadol, being an opioid drug, carries the risk of misuse and dependence. It must only be used under the guidance of a healthcare provider and with extreme caution. Constipation, nausea, vomiting, dizziness, and sleepiness are typical adverse effects. When taken excessively or improperly, serious adverse effects like respiratory depression might happen. The risk of respiratory depression and other severe adverse effects can rise when tapentadol is used with alcohol or other drugs that depress the central nervous system.