Get 10% Discount Apply Coupon Code "USA10" Tapentadol functions by two different mechanisms. It functions as a norepinephrine reuptake inhibitor as well as an opioid agonist. It is thought that this dual action reduces some of the potential negative effects of typical opioids while still relieving pain. The main reason tapeentadol is administered is to relieve acute pain that ranges from mild to severe. It can be applied to ailments like neuropathic pain brought on by diabetic peripheral neuropathy, surgical pain, and musculoskeletal pain.