What is Oxycodone medicine? Oxycodone medicine is used to relieve the severe pain in the body that works in the brain to change how your body feels and responds to pain. The extended-release capsules are expected to need pain medication around the clock for a long time. If you are taking an oxycodone product then ask your doctor or pharmacist for more information. It is also available in combination with acetaminophen, aspirin, and ibuprofen. How is oxycodone used? Oxycodone pills are usually swallowed but used as a suppository or are sometimes injected. If you have a nausea problem then it may help to take this drug with food. Oxycodone medicine comes in tablet form and is released slowly over the course of the day. It begins working to relieve pain in about 2 to 4 hours and reaches its peak effect in 15 to 30 hours. Keep store this medication at room temperature in the original container and out of reach of children and pets. It is important to take this medication prescribed by your doctor. If you miss more than 2 or 3 doses in a row then consult your doctor about how you should restart the medication. Do not try to take a double dose to make up for a missed one and it can be taken with or without food.